LARGE2

Across TCGA cell cohorts, LARGE2 mutation is significantly associated with the RNA expression of many other genes, with 383 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible LARGE2-associated genes across cancer lineages are KLK12, FAM237A, and OR4X2. Each is linked with LARGE2 in more than 1 cancer types. Because this analysis shows association rather than direction, both LARGE2-to-partner and partner-to-LARGE2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLK12 grouped by LARGE2-low versus LARGE2-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (LARGE2→partner) and Y-score (partner→LARGE2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	KLK12 →	+1.031	+4.930	<.001	.008	3	1
SOFT_TISSUE	FAM237A →	+0.043	+5.977	<.001	.001	3	1
CNS	OR4X2 →	+0.041	+4.981	<.001	.008	3	1
LARGE_INTESTINE	PLA2G3 →	+1.176	+2.438	<.001	<.001	3	1
LARGE_INTESTINE	GCAT →	+1.279	+3.459	<.001	<.001	3	1
LARGE_INTESTINE	HSCB →	+0.501	+3.169	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

KLK12 by LARGE2 expression — SOFT_TISSUE

Explore this box plot interactively →