LARGE2

Across TCGA pan-cancer cohorts, LARGE2 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of LARGE2’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where LARGE2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types LARGE2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

COAD, KIRC, and HNSC are the cancer types where LARGE2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in LARGE2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+4.352	<.001	11	view →
KIRC	Male	II,III,IV	−1.994	<.001	11	view →
HNSC	Male	IV	+1.980	<.001	11	view →
THCA	Male	III,IV	−1.177	<.001	10	view →
KIRP	All	II,III,IV	−2.362	<.001	9	view →
LUAD	Female	III,IV	+2.224	<.001	9	view →
READ	All	All	+3.242	.001	7	view →
LUSC	Male	All	+2.748	<.001	7	view →
LIHC	All	All	+0.962	<.001	7	view →
UCEC	All	All	+3.551	<.001	6	view →
BLCA	Male	All	+2.819	.002	6	view →
STAD	All	All	+1.536	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

LARGE2–COAD

Open the COAD breakdown →