KRTAP5-7

Across TCGA patient cohorts, KRTAP5-7 mutation is significantly associated with the RNA expression of many other genes, with 249 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-7-associated genes across cancer lineages are RN7SL402P, PRSS47, and IQCF1. Each is linked with KRTAP5-7 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-7-to-partner and partner-to-KRTAP5-7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL402P grouped by KRTAP5-7-low versus KRTAP5-7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-7→partner) and Y-score (partner→KRTAP5-7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL402P →	+0.256	+3.224	<.001	<.001	3	2
SKCM	PRSS47 →	+0.068	+3.490	.001	.008	3	1
SKCM	IQCF1 →	+0.138	+4.294	<.001	.001	3	1
SKCM	ARGFX →	+0.065	+3.978	<.001	.001	3	1
SKCM	MAGEB5 →	+0.038	+4.771	<.001	<.001	3	1
SKCM	MBD3L2B →	+0.373	+3.869	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 249 associations by consensus.

RN7SL402P by KRTAP5-7 expression — UCEC

Explore this box plot interactively →