KRTAP5-7

Across TCGA pan-cancer cohorts, KRTAP5-7 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KRTAP5-7 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher KRTAP5-7 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KRTAP5-7 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BLCA show a favorable association.

HNSC, BLCA, and UCEC are the cancer types where KRTAP5-7 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	II,III,IV	0.496	0.319	<.001	91	view →
BLCA	OS	Median	II,III,IV	0.778	0.660	.002	54	view →
UCEC	OS	Quartile	All	0.325	0.702	.006	36	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	18	view →
PRAD	DFS	Median	All	0.703	0.824	<.001	18	view →
KIRP	OS	Median	All	0.917	0.970	.018	18	view →
CHOL	OS	Median	All	0.755	0.410	.014	15	view →
LUSC	OS	Median	III,IV	0.641	0.407	.012	15	view →
STAD	OS	Tertile	III,IV	0.594	0.275	.011	12	view →
THYM	DFS	Tertile	All	1.000	0.851	.026	10	view →
THCA	DFS	Median	II,III,IV	0.793	0.912	.018	10	view →
LIHC	OS	Tertile	All	0.733	0.845	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KRTAP5-7–HNSC (OS)

Open the HNSC breakdown →