Q-omics provides the consensus-scored PRSS47 profile across patient tissues and cancer cell-line models. PRSS47 expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in KICH. Among the 18 cancer types available for tumor–normal comparison, PRSS47 is differentially expressed in 1, with the highest sampling consensus in LUSC. Additionally, PRSS47 RNA expression shows 7,038 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KICH, LUSC, and TGCT as cancer lineages where PRSS47 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PRSS47 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PRSS47 survival associations across molecular data types. PRSS47 RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PRSS47 RNA expression–survival associations across cancer types. High PRSS47 expression shows unfavorable associations in KICH, THCA, HNSC, READ and MESO, but favorable associations in UCS. The KICH Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KICH as the clearest survival context for PRSS47 RNA expression.
This table summarizes PRSS47 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for PRSS47. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PRSS47 shows lower tumor expression in LUSC. The LUSC box plot shows higher PRSS47 RNA expression in normal versus tumor tissue (log2 FC = −0.030, t-test p = .034).
This table shows molecular features associated with PRSS47 in patient tissues and cancer cell lines. In patient samples, PRSS47 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
