PRSS47

Across TCGA pan-cancer cohorts, PRSS47 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated PRSS47 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher PRSS47 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PRSS47 expression acts as an unfavorable survival marker, although some lineages such as UCS and PRAD show a favorable association.

KICH, THCA, and HNSC are the cancer types where PRSS47 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.250	0.893	<.001	78	view →
THCA	OS	Tertile	II,III,IV	0.796	0.993	.001	39	view →
HNSC	DFS	Tertile	III,IV	0.258	0.527	.009	39	view →
READ	DFS	Tertile	All	0.181	0.555	.010	36	view →
UCS	OS	Tertile	II,III,IV	0.875	0.398	.009	36	view →
DLBC	OS	Tertile	All	0.053	0.936	<.001	18	view →
MESO	OS	Tertile	All	0.252	0.558	.042	18	view →
LIHC	DFS	Tertile	II,III,IV	0.139	0.432	.024	18	view →
STAD	DFS	Tertile	IV	0.083	0.379	.001	12	view →
KIRC	DFS	Tertile	All	0.698	0.807	.022	12	view →
PRAD	DFS	Tertile	All	1.000	0.753	.033	12	view →
LUSC	OS	Tertile	III,IV	0.179	0.712	.020	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

PRSS47–KICH (OS)

Open the KICH breakdown →