KRTAP5-4

Across TCGA patient cohorts, KRTAP5-4 mutation is significantly associated with the RNA expression of many other genes, with 1,975 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-4-associated genes across cancer lineages are CCDC43, RPL23AP82, and KIF18B. Each is linked with KRTAP5-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-4-to-partner and partner-to-KRTAP5-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC43 grouped by KRTAP5-4-low versus KRTAP5-4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-4→partner) and Y-score (partner→KRTAP5-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCDC43 →	+0.691	+3.839	<.001	<.001	3	2
UCEC	RPL23AP82 →	+0.468	+3.592	.001	.001	3	2
UCEC	KIF18B →	+0.759	+2.721	.006	.003	3	2
UCEC	FANCA →	+0.782	+3.601	<.001	.001	3	2
UCEC	XPNPEP3 →	+0.599	+3.650	<.001	.001	3	2
UCEC	MFSD14C →	+0.852	+2.732	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,975 associations by consensus.

CCDC43 by KRTAP5-4 expression — UCEC

Explore this box plot interactively →