KRTAP5-4

Across TCGA pan-cancer cohorts, KRTAP5-4 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of KRTAP5-4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KRTAP5-4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRTAP5-4 is over-expressed in tumor, although a few such as KIRC show the opposite, repressed pattern.

COAD, KIRC, and READ are the cancer types where KRTAP5-4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRTAP5-4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.537	<.001	8	view →
KIRC	Male	II,III,IV	−0.058	<.001	5	view →
READ	All	All	+0.526	<.001	3	view →
KICH	All	All	+0.207	.010	3	view →
STAD	Male	All	+0.307	.023	2	view →
LIHC	All	All	+0.026	.008	2	view →
LUSC	All	All	+0.059	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

KRTAP5-4–COAD

Open the COAD breakdown →