KRTAP5-4

Across TCGA pan-cancer cohorts, KRTAP5-4 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated KRTAP5-4 data layer compared with 3 for mutation status.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher KRTAP5-4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KRTAP5-4 expression acts as an unfavorable survival marker, although some lineages such as READ and SCLC show a favorable association.

KIRC, ACC, and MESO are the cancer types where KRTAP5-4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Quartile	II,III,IV	0.362	0.584	<.001	133	view →
ACC	DFS	Tertile	III,IV	0.010	0.364	<.001	108	view →
MESO	OS	Tertile	All	0.052	0.528	.016	54	view →
HNSC	OS	Quartile	III,IV	0.145	0.471	.001	47	view →
DLBC	OS	Tertile	All	0.395	0.878	.001	45	view →
READ	DFS	Median	II,III,IV	0.698	0.333	.001	42	view →
SKCM	DFS	Tertile	IV	0.016	0.541	.008	21	view →
SCLC	OS	Quartile	All	0.784	0.485	.013	20	view →
UCEC	OS	Quartile	All	0.535	0.784	.006	20	view →
ESCA	OS	Median	All	0.629	1.000	.012	12	view →
KIRP	DFS	Tertile	All	0.802	0.539	.033	8	view →
BLCA	DFS	Tertile	All	0.207	0.370	.043	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

KRTAP5-4–KIRC (OS)

Open the KIRC breakdown →