KRTAP5-4

Across TCGA patient cohorts, KRTAP5-4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP5-4-associated genes across cancer lineages are STAT3_pY705, PKC-a, and Smac. Each is linked with KRTAP5-4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP5-4-to-partner and partner-to-KRTAP5-4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by KRTAP5-4-low versus KRTAP5-4-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP5-4→partner) and Y-score (partner→KRTAP5-4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	STAT3_pY705 →	-0.365	-2.459	.004	.020	3	2
SKCM	PKC-a →	-0.468	-2.459	.016	.020	3	1
SKCM	Smac →	+0.305	+2.182	.018	.033	3	1
UCEC	Caspase-7-cleavedD198 →	+0.806	+3.321	.009	.010	3	1
SKCM	Dvl3 →	-0.315	-3.584	.001	.002	2	1
UCEC	MEK1 →	+0.505	+3.321	.008	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

STAT3_pY705 by KRTAP5-4 expression — SKCM

Explore this box plot interactively →