Across TCGA patient cohorts, KRTAP4-6 mutation is significantly associated with the RNA expression of many other genes, with 94 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KRTAP4-6-associated genes across cancer lineages are TUBB4BP1, RN7SL419P, and PPIAP56. Each is linked with KRTAP4-6 in more than 1 cancer types. Because this analysis shows association rather than direction, both KRTAP4-6-to-partner and partner-to-KRTAP4-6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KRTAP4-6→partner) and Y-score (partner→KRTAP4-6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TUBB4BP1 →	+0.375	+5.857	<.001	.002	3	2
CESC	RN7SL419P →	+0.175	+4.364	<.001	.006	3	2
GBM	PPIAP56 →	+0.136	+4.969	.001	.009	3	1
GBM	REXO1L8P →	+0.092	+5.857	<.001	.002	3	1
BRCA	H3P46 →	+0.193	+7.731	<.001	.009	3	1
GBM	RNU6-822P →	+0.563	+6.189	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 94 associations by consensus.

Exploration

KRTAP4-6 survival (RNA) · tumor vs normal (RNA) · all KRTAP4-6 data types