Across TCGA pan-cancer cohorts, KRTAP4-6 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of KRTAP4-6’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where KRTAP4-6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KRTAP4-6 is over-expressed in tumor.

LUSC and LUAD are the cancer types where KRTAP4-6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KRTAP4-6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	Male	All	+0.022	.003	2	view →
LUAD	All	All	+0.008	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: KRTAP4-6 RNA expression & survival · all KRTAP4-6 data types