Across TCGA patient cohorts, KMT5A mutation is significantly associated with the RNA expression of many other genes, with 2,466 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KMT5A-associated genes across cancer lineages are MIR4510, RN7SL248P, and BMS1P13. Each is linked with KMT5A in more than 1 cancer types. Because this analysis shows association rather than direction, both KMT5A-to-partner and partner-to-KMT5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KMT5A→partner) and Y-score (partner→KMT5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MIR4510 →	+0.297	+5.342	<.001	.002	3	2
UCEC	RN7SL248P →	+0.046	+2.783	<.001	.009	3	2
UCEC	BMS1P13 →	+0.031	+1.862	.001	.009	3	2
CESC	RN7SL62P →	+0.102	+4.812	<.001	.006	3	1
CESC	RN7SL415P →	+0.105	+4.812	<.001	.006	3	1
CESC	RN7SL810P →	+0.159	+4.874	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,466 associations by consensus.

Exploration

KMT5A survival (RNA) · tumor vs normal (RNA) · all KMT5A data types