KLK15

Across TCGA cell cohorts, KLK15 mutation is significantly associated with the mutation status of many other genes, with 1,323 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KLK15-associated genes across cancer lineages are IGSF9B, MEGF8, and SASH1. Each is linked with KLK15 in more than 2 cancer types. Because this analysis shows association rather than direction, both KLK15-to-partner and partner-to-KLK15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGSF9B grouped by KLK15-low versus KLK15-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLK15→partner) and Y-score (partner→KLK15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IGSF9B →	+3.303	+3.478	.006	.006	1	3
SKIN	MEGF8 →	+2.146	+3.860	.007	.007	1	3
SKIN	SASH1 →	+3.638	+4.117	.002	.002	1	3
SKIN	ARFGEF3 →	+3.316	+3.906	.004	.004	1	3
LUNG_NSCLC_LUAD	TBX18 →	+3.718	+3.718	.003	.003	1	3
SKIN	MLH3 →	+3.638	+4.117	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,323 associations by consensus.

IGSF9B by KLK15 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →