KLK15

Across TCGA pan-cancer cohorts, KLK15 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated KLK15 data layer compared with 5 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher KLK15 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated KLK15 expression acts as an unfavorable survival marker, although some lineages such as ACC and UVM show a favorable association.

ACC, KIRC, and BLCA are the cancer types where KLK15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	II,III,IV	0.596	0.197	<.001	130	view →
KIRC	OS	Median	All	0.815	0.905	.001	78	view →
BLCA	DFS	Tertile	III,IV	0.305	0.526	.001	44	view →
UVM	OS	Quartile	All	1.000	0.508	.004	42	view →
THYM	DFS	Tertile	III,IV	0.378	0.934	.008	34	view →
BRCA	OS	Quartile	II,III,IV	0.543	0.565	.003	26	view →
LIHC	OS	Quartile	All	0.657	0.820	.005	25	view →
LGG	OS	Tertile	All	0.608	0.399	.002	22	view →
DLBC	OS	Tertile	III,IV	0.272	1.000	.017	22	view →
LAML	DFS	Quartile	All	0.901	0.358	<.001	20	view →
ESCA	OS	Quartile	All	0.330	1.000	.006	19	view →
GBM	DFS	Tertile	All	0.171	0.277	.027	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

KLK15–ACC (DFS)

Open the ACC breakdown →