KLK15

Across TCGA pan-cancer cohorts, KLK15 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KLK15’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KLK15 RNA is repressed in tumor relative to normal tissue. In most cancer types KLK15 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

COAD, THCA, and KICH are the cancer types where KLK15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLK15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	−1.330	<.001	10	view →
THCA	Male	III,IV	−1.215	<.001	10	view →
KICH	Female	All	+4.633	<.001	9	view →
KIRC	Male	II,III,IV	−0.292	<.001	4	view →
LUSC	All	All	+0.081	.002	4	view →
KIRP	Female	All	−0.246	.002	3	view →
PRAD	All	All	+1.684	<.001	2	view →
STAD	Male	All	+0.311	.019	2	view →
UCEC	All	All	+0.091	.042	2	view →
BLCA	All	III,IV	+0.032	.015	2	view →
LIHC	All	All	+0.029	.015	2	view →
READ	All	All	−1.248	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KLK15–COAD

Open the COAD breakdown →