KLF14

Across TCGA patient cohorts, KLF14 mutation is significantly associated with the RNA expression of many other genes, with 1,535 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KLF14-associated genes across cancer lineages are MREGP1, RNU6-1153P, and MIR577. Each is linked with KLF14 in more than 1 cancer types. Because this analysis shows association rather than direction, both KLF14-to-partner and partner-to-KLF14 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MREGP1 grouped by KLF14-low versus KLF14-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KLF14→partner) and Y-score (partner→KLF14) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MREGP1 →	+0.268	+2.613	<.001	.007	3	2
UCEC	RNU6-1153P →	+0.537	+2.540	.007	.002	3	2
COAD	MIR577 →	+0.727	+4.070	<.001	.009	3	2
SKCM	MTND4LP3 →	+0.159	+6.797	<.001	<.001	3	2
UCEC	TOP3B →	+0.139	+2.530	.004	.009	3	1
UCEC	SRRD →	+0.615	+3.499	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,535 associations by consensus.

MREGP1 by KLF14 expression — UCEC

Explore this box plot interactively →