KLF14

Across TCGA pan-cancer cohorts, KLF14 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of KLF14’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where KLF14 RNA is repressed in tumor relative to normal tissue. In most cancer types KLF14 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and BRCA are the cancer types where KLF14 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KLF14 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	III,IV	−0.117	<.001	11	view →
HNSC	All	II,III,IV	+0.450	.001	9	view →
BRCA	All	III,IV	−0.744	<.001	6	view →
UCEC	All	II,III,IV	−0.694	<.001	6	view →
KICH	Female	All	−0.169	<.001	5	view →
KIRP	All	III,IV	+0.414	.044	1	view →
LUSC	All	II,III,IV	+0.183	.043	1	view →
CHOL	All	All	+0.053	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

KLF14–KIRC

Open the KIRC breakdown →