Q-omics provides the consensus-scored KISS1 profile across patient tissues and cancer cell-line models. KISS1 expression is associated with patient survival in 28 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, KISS1 is differentially expressed in 15, with the highest sampling consensus in COAD. Additionally, KISS1 RNA expression shows 12,303 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, COAD, and TGCT as cancer lineages where KISS1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for KISS1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes KISS1 survival associations across molecular data types. KISS1 RNA expression shows survival associations in the most cancer types (28), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible KISS1 RNA expression–survival associations across cancer types. High KISS1 expression shows unfavorable associations in KIRP, KIRC, MESO, UVM and HNSC, but favorable associations in BLCA. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for KISS1 RNA expression.
This table summarizes KISS1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 15. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for KISS1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. KISS1 shows higher tumor expression in COAD, LIHC, THCA, LUAD, KIRC and BRCA. The COAD box plot shows higher KISS1 RNA expression in tumor versus normal tissue (log2 FC = +1.254, t-test p < 0.001).
This table shows molecular features associated with KISS1 in patient tissues and cancer cell lines. In patient samples, KISS1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, KISS1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_SCLC, while CRISPR and shRNA rows add functional-dependency signals in BONE and LARGE_INTESTINE.
