KISS1

Across TCGA pan-cancer cohorts, KISS1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated KISS1 data layer compared with 28 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher KISS1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated KISS1 expression acts as an unfavorable survival marker.

THYM, LIHC, and PRAD are the cancer types where KISS1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
LIHC	OS	Median	III,IV	0.093	0.649	<.001	30	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

KISS1–THYM (OS)

Open the THYM breakdown →