KISS1

Across TCGA patient cohorts, KISS1 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible KISS1-associated genes across cancer lineages are RNU7-159P, RNA5SP134, and RN7SKP183. Each is linked with KISS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both KISS1-to-partner and partner-to-KISS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU7-159P grouped by KISS1-low versus KISS1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KISS1→partner) and Y-score (partner→KISS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU7-159P →	+1.193	+7.816	<.001	.008	3	1
SKCM	RNA5SP134 →	+0.948	+7.816	<.001	.008	3	1
SKCM	RN7SKP183 →	+0.429	+7.816	<.001	.008	3	1
SKCM	RNU6-1052P →	+0.908	+7.816	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

RNU7-159P by KISS1 expression — SKCM

Explore this box plot interactively →