KIF15

Across TCGA cell cohorts, KIF15 mutation is significantly associated with the RNA expression of many other genes, with 492 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KIF15-associated genes across cancer lineages are PKD2L1, LCE1D, and PCSK9. Each is linked with KIF15 in more than 2 cancer types. Because this analysis shows association rather than direction, both KIF15-to-partner and partner-to-KIF15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PKD2L1 grouped by KIF15-low versus KIF15-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIF15→partner) and Y-score (partner→KIF15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PKD2L1 →	+0.204	+2.619	<.001	.007	3	3
OESOPHAGUS	LCE1D →	+0.206	+4.906	<.001	.006	3	2
LARGE_INTESTINE	PCSK9 →	+1.684	+3.364	.008	.002	3	2
BLOOD_Leukemia	PLA2G3 →	+0.394	+3.392	<.001	<.001	3	2
BLOOD_Leukemia	KISS1R →	+0.687	+3.351	.001	.003	3	2
BLOOD_Leukemia	AFG1L →	+0.585	+3.120	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 492 associations by consensus.

PKD2L1 by KIF15 expression — BLOOD_Leukemia

Explore this box plot interactively →