KIF15

Across TCGA pan-cancer cohorts, KIF15 RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated KIF15 data layer compared with 7 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher KIF15 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated KIF15 expression acts as an unfavorable survival marker, although some lineages such as UCS and READ show a favorable association.

KIRP, ACC, and MESO are the cancer types where KIF15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.777	0.923	<.001	158	view →
ACC	OS	Median	All	0.371	0.818	<.001	141	view →
MESO	OS	Median	All	0.389	0.695	<.001	132	view →
LIHC	OS	Median	All	0.609	0.760	<.001	101	view →
KICH	DFS	Median	III,IV	0.335	1.000	<.001	98	view →
UCS	OS	Median	II,III,IV	0.599	0.240	.006	78	view →
KIRC	DFS	Tertile	All	0.523	0.719	<.001	70	view →
UVM	DFS	Quartile	III,IV	0.188	0.841	<.001	56	view →
READ	OS	Tertile	All	0.958	0.436	<.001	55	view →
LGG	OS	Median	All	0.730	0.893	<.001	47	view →
PAAD	DFS	Median	All	0.177	0.389	<.001	44	view →
SARC	DFS	Median	All	0.403	0.624	<.001	41	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

KIF15–KIRP (DFS)

Open the KIRP breakdown →