KIAA0319L

Across TCGA patient cohorts, KIAA0319L mutation is significantly associated with the RNA expression of many other genes, with 2,831 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KIAA0319L-associated genes across cancer lineages are SPATA5L1, PKM, and TIPIN. Each is linked with KIAA0319L in more than 2 cancer types. Because this analysis shows association rather than direction, both KIAA0319L-to-partner and partner-to-KIAA0319L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPATA5L1 grouped by KIAA0319L-low versus KIAA0319L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KIAA0319L→partner) and Y-score (partner→KIAA0319L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SPATA5L1 →	+0.455	+2.142	<.001	<.001	3	3
UCEC	PKM →	+0.397	+1.716	.006	.004	3	3
COAD	TIPIN →	+0.599	+3.200	.002	.009	3	3
UCEC	ORC1 →	+0.621	+2.086	<.001	<.001	3	3
UCEC	NFX1 →	+0.268	+2.055	.007	.005	3	3
UCEC	LRRC59 →	+0.382	+2.010	.006	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,831 associations by consensus.

SPATA5L1 by KIAA0319L expression — UCEC

Explore this box plot interactively →