KIAA0319L

Across TCGA pan-cancer cohorts, KIAA0319L RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated KIAA0319L data layer compared with 6 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher KIAA0319L RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KIAA0319L expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

LIHC, LGG, and MESO are the cancer types where KIAA0319L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.543	0.761	<.001	67	view →
LGG	OS	Median	All	0.366	0.531	<.001	48	view →
MESO	DFS	Median	II,III,IV	0.233	0.668	.001	48	view →
KIRC	OS	Tertile	All	0.764	0.537	<.001	46	view →
BRCA	OS	Tertile	All	0.950	0.892	.002	30	view →
LUAD	OS	Tertile	III,IV	0.404	0.201	.011	29	view →
COAD	OS	Median	II,III,IV	0.845	0.715	.005	23	view →
THCA	DFS	Median	II,III,IV	0.897	0.778	.008	20	view →
ESCA	DFS	Tertile	II,III,IV	0.488	0.271	.005	20	view →
PRAD	DFS	Median	All	0.867	0.713	<.001	18	view →
HNSC	DFS	Quartile	All	0.275	0.569	.013	17	view →
SKCM	OS	Median	IV	0.151	0.655	.008	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

KIAA0319L–LIHC (OS)

Open the LIHC breakdown →