KIAA0319L

Across TCGA pan-cancer cohorts, KIAA0319L RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KIAA0319L’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where KIAA0319L RNA is repressed in tumor relative to normal tissue. In most cancer types KIAA0319L is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

KICH, LIHC, and STAD are the cancer types where KIAA0319L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KIAA0319L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.025	<.001	10	view →
LIHC	Female	All	+0.895	<.001	7	view →
STAD	Male	All	+0.873	<.001	7	view →
BLCA	All	III,IV	+0.627	.001	6	view →
BRCA	All	II,III,IV	+0.400	<.001	6	view →
HNSC	All	All	+0.315	.003	6	view →
LUSC	All	II,III,IV	−0.564	<.001	4	view →
CHOL	All	All	+1.620	<.001	3	view →
THCA	Male	III,IV	−0.514	.002	3	view →
PRAD	All	All	+0.775	<.001	2	view →
KIRC	All	II,III,IV	−0.225	.024	2	view →
KIRP	Male	All	−0.328	.030	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KIAA0319L–KICH

Open the KICH breakdown →