Across TCGA cell cohorts, KHDC3L mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible KHDC3L-associated genes across cancer lineages are SLC22A8, C1orf87, and SPAG11B. Each is linked with KHDC3L in more than 1 cancer types. Because this analysis shows association rather than direction, both KHDC3L-to-partner and partner-to-KHDC3L results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KHDC3L→partner) and Y-score (partner→KHDC3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC22A8 →	+0.038	+4.922	<.001	.009	3	1
BLOOD_Leukemia	C1orf87 →	+0.015	+5.201	<.001	.006	3	1
BLOOD_Leukemia	SPAG11B →	+0.056	+5.201	.002	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.015	+5.201	<.001	.006	3	1
BLOOD_Leukemia	ZCCHC13 →	+0.030	+6.569	<.001	<.001	3	1
BLOOD_Leukemia	GRXCR1 →	+0.023	+6.569	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

KHDC3L survival (RNA) · tumor vs normal (RNA) · all KHDC3L data types