KDM4A

Across TCGA patient cohorts, KDM4A mutation is significantly associated with the RNA expression of many other genes, with 5,111 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KDM4A-associated genes across cancer lineages are RN7SKP107, MIR320A, and EIF5AL1. Each is linked with KDM4A in more than 2 cancer types. Because this analysis shows association rather than direction, both KDM4A-to-partner and partner-to-KDM4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP107 grouped by KDM4A-low versus KDM4A-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KDM4A→partner) and Y-score (partner→KDM4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RN7SKP107 →	+0.057	+4.455	<.001	.005	3	3
COAD	MIR320A →	+0.770	+3.080	.002	.001	3	3
COAD	EIF5AL1 →	+1.001	+3.486	.003	.002	3	3
UCEC	CMC2 →	+0.497	+2.857	<.001	<.001	3	3
BRCA	RN7SL248P →	+0.064	+4.464	<.001	.005	3	2
BRCA	SMIM7P1 →	+0.059	+4.628	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,111 associations by consensus.

RN7SKP107 by KDM4A expression — BLCA

Explore this box plot interactively →