KDM4A

Across TCGA pan-cancer cohorts, KDM4A RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of KDM4A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where KDM4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types KDM4A is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where KDM4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KDM4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.727	<.001	11	view →
BLCA	All	All	+0.864	<.001	9	view →
LIHC	Female	II,III,IV	+1.049	<.001	7	view →
STAD	All	II,III,IV	+0.870	<.001	6	view →
COAD	Female	II,III,IV	−0.718	<.001	6	view →
CHOL	All	All	+1.953	<.001	5	view →
LUSC	All	All	+0.553	<.001	5	view →
BRCA	All	II,III,IV	+0.322	<.001	4	view →
THCA	Male	III,IV	−0.584	.027	3	view →
UCEC	All	III,IV	+0.816	.030	2	view →
PRAD	All	All	+0.248	.035	2	view →
READ	All	II,III,IV	−0.665	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

KDM4A–HNSC

Open the HNSC breakdown →