KCNQ4

Across TCGA patient cohorts, KCNQ4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,108 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible KCNQ4-associated genes across cancer lineages are CXCL8, ARHGAP27P2, and MRPS14. Each is linked with KCNQ4 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCNQ4-to-partner and partner-to-KCNQ4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, KCNQ4 versus CXCL8 in LUAD, with a Pearson correlation of 0.64.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNQ4→partner) and Y-score (partner→KCNQ4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	CXCL8 →	+2.477	+1.355	<.001	.001	3	2
LUAD	ARHGAP27P2 →	-0.594	-1.271	.003	.002	3	2
LSCC	MRPS14 →	-0.609	-1.382	<.001	<.001	3	2
LSCC	SLX4IP →	-0.633	-1.093	.002	.003	3	2
GBM	TMEM184C →	-0.422	-1.431	.001	.003	3	2
LSCC	SYCP2 →	-1.071	-0.940	.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,108 associations by consensus.

KCNQ4 vs CXCL8 — LUAD

Explore this scatter interactively →