KCNQ4

Across TCGA pan-cancer cohorts, KCNQ4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of KCNQ4’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where KCNQ4 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNQ4 is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and BRCA are the cancer types where KCNQ4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNQ4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−3.512	<.001	11	view →
THCA	All	II,III,IV	−0.252	<.001	9	view →
BRCA	All	III,IV	−1.000	<.001	8	view →
UCEC	All	II,III,IV	−1.524	<.001	6	view →
CHOL	All	All	+0.973	<.001	5	view →
HNSC	All	IV	−0.761	.001	5	view →
LIHC	All	All	+0.251	.005	5	view →
COAD	All	All	−0.501	.010	4	view →
STAD	Female	All	−1.651	.006	3	view →
READ	All	All	−1.151	.021	2	view →
PRAD	All	All	−0.655	<.001	2	view →
KIRC	Female	All	+0.476	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

KCNQ4–BLCA

Open the BLCA breakdown →