KCNQ4

Across TCGA pan-cancer cohorts, KCNQ4 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated KCNQ4 data layer compared with 6 for mutation status.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher KCNQ4 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated KCNQ4 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

SKCM, ACC, and LIHC are the cancer types where KCNQ4 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.265	0.409	<.001	66	view →
ACC	DFS	Tertile	All	0.405	0.769	<.001	52	view →
LIHC	OS	Quartile	All	0.635	0.885	<.001	48	view →
HNSC	OS	Median	IV	0.441	0.253	<.001	43	view →
UCEC	OS	Median	II,III,IV	0.813	0.885	.008	34	view →
OV	DFS	Quartile	All	0.598	0.459	.003	32	view →
LUAD	OS	Median	II,III,IV	0.627	0.490	.005	31	view →
LGG	DFS	Tertile	All	0.289	0.502	.001	30	view →
COAD	OS	Median	III,IV	0.690	0.866	.005	27	view →
READ	DFS	Tertile	III,IV	0.232	1.000	.003	19	view →
ESCA	DFS	Median	II,III,IV	0.394	0.212	.010	17	view →
SCLC	DFS	Median	All	0.917	0.350	.002	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

KCNQ4–SKCM (OS)

Open the SKCM breakdown →