KCND3

Across TCGA cell cohorts, KCND3 mutation is significantly associated with the RNA expression of many other genes, with 301 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible KCND3-associated genes across cancer lineages are OR4E1, GGTLC2, and MT1A. Each is linked with KCND3 in more than 1 cancer types. Because this analysis shows association rather than direction, both KCND3-to-partner and partner-to-KCND3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4E1 grouped by KCND3-low versus KCND3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCND3→partner) and Y-score (partner→KCND3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OR4E1 →	+0.061	+4.321	<.001	.009	3	1
SKIN	GGTLC2 →	+0.025	+3.103	<.001	.004	3	1
SKIN	MT1A →	+1.866	+3.626	<.001	.003	3	1
LARGE_INTESTINE	DEPDC5 →	+0.477	+3.169	.008	.009	3	1
LARGE_INTESTINE	DESI1 →	+0.479	+3.169	.001	.009	3	1
LARGE_INTESTINE	RNF125 →	+0.944	+3.386	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 301 associations by consensus.

OR4E1 by KCND3 expression — CNS

Explore this box plot interactively →