KCND3

Across TCGA pan-cancer cohorts, KCND3 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated KCND3 data layer compared with 5 for mutation status.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher KCND3 RNA is associated with better overall survival. In most high-consensus cancer types, elevated KCND3 expression acts as an unfavorable survival marker, although some lineages such as BRCA and SARC show a favorable association.

BRCA, BLCA, and UVM are the cancer types where KCND3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	OS	Quartile	All	0.953	0.885	.001	68	view →
BLCA	OS	Median	All	0.440	0.733	<.001	54	view →
UVM	DFS	Tertile	III,IV	0.204	0.683	.005	45	view →
SARC	OS	Median	All	0.834	0.647	<.001	45	view →
MESO	OS	Median	All	0.483	0.291	.005	33	view →
UCS	DFS	Tertile	II,III,IV	0.492	0.128	.012	30	view →
LUAD	OS	Median	II,III,IV	0.843	0.651	.006	29	view →
LUSC	DFS	Quartile	All	0.287	0.520	<.001	28	view →
KIRP	OS	Tertile	All	0.815	0.595	.008	26	view →
CESC	DFS	Tertile	All	0.871	0.730	.005	24	view →
KIRC	DFS	Median	All	0.527	0.715	.009	20	view →
PRAD	DFS	Median	All	0.868	0.704	<.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

KCND3–BRCA (OS)

Open the BRCA breakdown →