KCNA3

Across TCGA patient cohorts, KCNA3 mutation is significantly associated with the RNA expression of many other genes, with 5,032 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KCNA3-associated genes across cancer lineages are BUB1B, PTH1R, and GMEB1. Each is linked with KCNA3 in more than 2 cancer types. Because this analysis shows association rather than direction, both KCNA3-to-partner and partner-to-KCNA3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BUB1B grouped by KCNA3-low versus KCNA3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KCNA3→partner) and Y-score (partner→KCNA3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BUB1B →	+0.822	+2.110	<.001	<.001	3	3
UCEC	PTH1R →	-0.552	-2.885	.008	.001	3	3
UCEC	GMEB1 →	+0.333	+3.753	<.001	<.001	3	3
UCEC	CDC25A →	+0.920	+3.044	<.001	<.001	3	3
UCEC	SFXN1 →	+0.601	+3.044	<.001	<.001	3	3
UCEC	LEO1 →	+0.423	+1.868	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,032 associations by consensus.

BUB1B by KCNA3 expression — UCEC

Explore this box plot interactively →