KCNA3

Across TCGA pan-cancer cohorts, KCNA3 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of KCNA3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where KCNA3 RNA is repressed in tumor relative to normal tissue. In most cancer types KCNA3 is over-expressed in tumor, although a few such as COAD and LUSC show the opposite, repressed pattern.

COAD, KIRC, and LUSC are the cancer types where KCNA3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in KCNA3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	−1.538	<.001	11	view →
KIRC	Male	All	+0.790	<.001	11	view →
LUSC	Female	II,III,IV	−2.777	<.001	8	view →
UCEC	All	II,III,IV	−0.372	.008	6	view →
LUAD	Male	All	−1.190	<.001	5	view →
THCA	All	All	−0.518	.001	4	view →
LIHC	Male	All	−0.357	<.001	4	view →
READ	All	All	−1.058	.002	3	view →
KICH	All	II,III,IV	−0.416	.003	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

KCNA3–COAD

Open the COAD breakdown →