KANTR

Across TCGA patient cohorts, KANTR mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible KANTR-associated genes across cancer lineages are IRS1, STAT3_pY705, and Syk. Each is linked with KANTR in more than 1 cancer types. Because this analysis shows association rather than direction, both KANTR-to-partner and partner-to-KANTR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IRS1 grouped by KANTR-low versus KANTR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (KANTR→partner) and Y-score (partner→KANTR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IRS1 →	-0.292	-3.000	.007	.036	3	1
UCEC	STAT3_pY705 →	-0.446	-3.321	.001	.010	3	1
UCEC	Syk →	+0.506	+3.335	.010	.005	3	1
UCEC	Tuberin_pT1462 →	+0.248	+3.321	.040	.010	3	1
UCEC	VHL →	-1.278	-3.169	<.001	.019	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.630	+2.817	.018	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IRS1 by KANTR expression — UCEC

Explore this box plot interactively →