IQCC

Across TCGA patient cohorts, IQCC RNA expression is significantly associated with the protein abundance of many other proteins, with 13,260 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IQCC-associated proteins across cancer lineages are VEZF1, KHDRBS1_S58, and RPA2. Each is linked with IQCC in more than 5 cancer types. Because this analysis shows association rather than direction, both IQCC-to-partner and partner-to-IQCC results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IQCC versus VEZF1 in BRCA, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IQCC→partner) and Y-score (partner→IQCC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VEZF1 →	+0.499	+0.599	<.001	<.001	3	6
PDAC	KHDRBS1_S58 →	+0.431	+0.370	.002	<.001	3	6
GBM	RPA2 →	+0.356	+0.597	<.001	<.001	3	6
HNSC	ZMYM3 →	+0.353	+0.466	<.001	.002	3	5
GBM	ZMYM4 →	+0.275	+0.311	<.001	<.001	3	5
LUAD	RCC1 →	+0.431	+0.606	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,260 associations by consensus.

IQCC vs VEZF1 — BRCA

Explore this scatter interactively →