IQCC

Across TCGA pan-cancer cohorts, IQCC RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated IQCC data layer compared with 1 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher IQCC RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated IQCC expression acts as an unfavorable survival marker, although some lineages such as BRCA and READ show a favorable association.

LIHC, BRCA, and ACC are the cancer types where IQCC RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.432	0.647	<.001	73	view →
BRCA	OS	Median	III,IV	0.951	0.851	<.001	58	view →
ACC	DFS	Quartile	All	0.236	0.755	<.001	54	view →
LGG	DFS	Median	All	0.614	0.856	<.001	54	view →
KICH	DFS	Quartile	III,IV	0.179	0.913	.003	49	view →
READ	OS	Quartile	All	0.885	0.579	.003	42	view →
PAAD	DFS	Quartile	All	0.468	0.193	.001	36	view →
STAD	DFS	Median	All	0.621	0.448	.001	30	view →
KIRC	DFS	Quartile	IV	0.210	0.536	.014	29	view →
LUAD	OS	Quartile	II,III,IV	0.415	0.095	.013	23	view →
HNSC	OS	Median	III,IV	0.802	0.689	.009	22	view →
THYM	DFS	Tertile	All	1.000	0.729	.003	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

IQCC–LIHC (DFS)

Open the LIHC breakdown →