IQCC

Across TCGA pan-cancer cohorts, IQCC RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of IQCC’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IQCC RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IQCC is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where IQCC tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IQCC RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.896	<.001	10	view →
LIHC	Female	II,III,IV	+0.972	<.001	9	view →
BLCA	Female	III,IV	+1.142	<.001	8	view →
LUAD	Male	All	+0.731	<.001	8	view →
COAD	Female	II,III,IV	+0.713	<.001	8	view →
KICH	All	All	−0.924	<.001	6	view →
STAD	Male	II,III,IV	+0.842	<.001	6	view →
THCA	Male	All	−0.481	<.001	6	view →
BRCA	All	All	+0.435	<.001	6	view →
CHOL	Male	All	+2.201	<.001	5	view →
LUSC	All	All	+0.706	<.001	5	view →
ESCA	All	All	+0.385	.010	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

IQCC–HNSC

Open the HNSC breakdown →