IL6ST

Across TCGA patient cohorts, IL6ST RNA expression is significantly associated with the protein abundance of many other proteins, with 20,640 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IL6ST-associated proteins across cancer lineages are SERPINA5, LRPPRC, and RPL12_S38. Each is linked with IL6ST in more than 6 cancer types. Because this analysis shows association rather than direction, both IL6ST-to-partner and partner-to-IL6ST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6ST versus SERPINA5 in OV, with a Pearson correlation of 0.40.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6ST→partner) and Y-score (partner→IL6ST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINA5 →	+0.803	+0.638	.005	.001	3	7
LSCC	LRPPRC →	-0.422	-0.537	<.001	<.001	3	7
BRCA	RPL12_S38 →	-0.872	-1.232	<.001	<.001	3	6
OV	SLIRP →	-0.542	-0.731	<.001	<.001	3	6
HNSC	NAA50 →	-0.258	-0.551	<.001	.001	3	6
PDAC	CLPX →	-0.310	-0.269	.002	.008	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,640 associations by consensus.

IL6ST vs SERPINA5 — OV

Explore this scatter interactively →