IL6ST

Across TCGA pan-cancer cohorts, IL6ST RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated IL6ST data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher IL6ST RNA is associated with better overall survival. In most high-consensus cancer types, elevated IL6ST expression acts as an unfavorable survival marker, although some lineages such as KIRC and BRCA show a favorable association.

KIRC, BRCA, and HNSC are the cancer types where IL6ST RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.717	0.548	<.001	102	view →
BRCA	OS	Median	II,III,IV	0.942	0.881	<.001	83	view →
HNSC	DFS	Median	All	0.445	0.285	<.001	52	view →
LUAD	DFS	Median	III,IV	0.625	0.387	.001	48	view →
UVM	DFS	Tertile	III,IV	0.237	0.866	<.001	42	view →
LGG	OS	Median	All	0.857	0.935	<.001	33	view →
KICH	OS	Quartile	All	0.619	1.000	.009	21	view →
LIHC	OS	Quartile	II,III,IV	0.815	0.626	.005	19	view →
SKCM	OS	Tertile	III,IV	0.528	0.229	.002	18	view →
PRAD	DFS	Tertile	All	0.979	0.897	<.001	14	view →
DLBC	DFS	Median	IV	0.128	1.000	.017	13	view →
MESO	OS	Quartile	All	0.650	0.178	.026	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

IL6ST–KIRC (OS)

Open the KIRC breakdown →