IL6ST

Across TCGA pan-cancer cohorts, IL6ST RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of IL6ST’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where IL6ST RNA is repressed in tumor relative to normal tissue. In most cancer types IL6ST is over-expressed in tumor, although a few such as BLCA and LUAD show the opposite, repressed pattern.

BLCA, LUAD, and COAD are the cancer types where IL6ST tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL6ST RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	−2.091	<.001	11	view →
LUAD	Female	III,IV	−1.097	<.001	11	view →
COAD	Female	All	−1.122	<.001	10	view →
LUSC	Female	II,III,IV	−2.244	<.001	7	view →
UCEC	All	All	−1.373	<.001	6	view →
KICH	All	All	−1.421	<.001	5	view →
HNSC	Male	All	−0.586	.009	5	view →
READ	Female	All	−1.815	.001	2	view →
PAAD	Female	All	−0.650	.027	2	view →
KIRP	All	All	−0.531	<.001	2	view →
PRAD	All	All	−0.446	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

IL6ST–BLCA

Open the BLCA breakdown →