IL6ST

Across TCGA patient cohorts, IL6ST protein abundance is significantly associated with the RNA expression of many other genes, with 19,530 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible IL6ST-associated genes across cancer lineages are CIP2A, DIAPH3, and RFC4. Each is linked with IL6ST in more than 6 cancer types. Because this analysis shows association rather than direction, both IL6ST-to-partner and partner-to-IL6ST results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, IL6ST versus CIP2A in UCEC, with a Pearson correlation of -0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL6ST→partner) and Y-score (partner→IL6ST) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CIP2A →	-1.004	-0.331	<.001	.001	3	7
UCEC	DIAPH3 →	-1.028	-0.419	<.001	.002	3	6
LSCC	RFC4 →	-0.868	-0.292	<.001	<.001	3	6
LUAD	TRIP13 →	-1.124	-0.287	<.001	<.001	3	6
BRCA	CBX7 →	+0.789	+0.607	<.001	<.001	3	5
GBM	NEIL3 →	-1.114	-0.253	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,530 associations by consensus.

IL6ST vs CIP2A — UCEC

Explore this scatter interactively →