IL22

Across TCGA patient cohorts, IL22 mutation is significantly associated with the RNA expression of many other genes, with 954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL22-associated genes across cancer lineages are IGLVI-42, RNU6-42P, and RNA5SP113. Each is linked with IL22 in more than 1 cancer types. Because this analysis shows association rather than direction, both IL22-to-partner and partner-to-IL22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGLVI-42 grouped by IL22-low versus IL22-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL22→partner) and Y-score (partner→IL22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	IGLVI-42 →	+0.062	+4.039	<.001	.009	3	2
UCEC	RNU6-42P →	+0.763	+2.294	<.001	.001	3	2
UCEC	RNA5SP113 →	+0.310	+3.003	<.001	.007	3	2
UCEC	TDGF1P1 →	+0.081	+2.720	<.001	.004	3	2
UCEC	PDLIM3 →	+0.909	+2.648	.001	.005	3	2
UCEC	BPGM →	+0.457	+2.906	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 954 associations by consensus.

IGLVI-42 by IL22 expression — SKCM

Explore this box plot interactively →