IL22

Across TCGA pan-cancer cohorts, IL22 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of IL22’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IL22 RNA is repressed in tumor relative to normal tissue. In most cancer types IL22 is over-expressed in tumor, although a few such as HNSC and THCA show the opposite, repressed pattern.

HNSC, KIRC, and THCA are the cancer types where IL22 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL22 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	II,III,IV	−0.838	<.001	10	view →
KIRC	Male	All	+0.013	.009	3	view →
THCA	All	All	−0.027	.003	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

IL22–HNSC

Open the HNSC breakdown →