IL1RN

Across TCGA patient cohorts, IL1RN mutation is significantly associated with the RNA expression of many other genes, with 1,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IL1RN-associated genes across cancer lineages are CCT5, NCAPD3, and HOMER1. Each is linked with IL1RN in more than 1 cancer types. Because this analysis shows association rather than direction, both IL1RN-to-partner and partner-to-IL1RN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCT5 grouped by IL1RN-low versus IL1RN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IL1RN→partner) and Y-score (partner→IL1RN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT5 →	+0.747	+3.376	.001	.004	3	2
UCEC	NCAPD3 →	+0.863	+3.467	<.001	.002	3	2
SKCM	HOMER1 →	+0.720	+2.143	.005	.009	3	2
SKCM	CXADR →	+0.953	+3.584	.003	.002	3	2
UCEC	BUB1B →	+0.806	+2.595	.008	.006	3	2
SKCM	MAGOH →	+0.440	+2.729	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,825 associations by consensus.

CCT5 by IL1RN expression — UCEC

Explore this box plot interactively →