IL1RN

Across TCGA pan-cancer cohorts, IL1RN RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of IL1RN’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where IL1RN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types IL1RN is over-expressed in tumor, although a few such as LIHC and KICH show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where IL1RN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IL1RN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	+1.923	<.001	11	view →
THCA	All	All	+0.841	<.001	8	view →
LIHC	Female	All	−2.291	<.001	7	view →
KICH	All	All	−1.104	<.001	7	view →
UCEC	All	III,IV	+0.957	.032	6	view →
CHOL	All	All	−2.661	<.001	5	view →
BRCA	All	All	+0.685	<.001	4	view →
HNSC	Female	All	−1.462	.003	2	view →
LUSC	Male	All	+1.130	<.001	2	view →
PRAD	All	All	−0.833	<.001	2	view →
STAD	All	IV	−0.780	.040	2	view →
LUAD	Male	All	−0.741	.025	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

IL1RN–COAD

Open the COAD breakdown →