IKZF2

Across TCGA patient cohorts, IKZF2 mutation is significantly associated with the RNA expression of many other genes, with 5,095 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible IKZF2-associated genes across cancer lineages are CENPM, UBE2S, and KIF20A. Each is linked with IKZF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both IKZF2-to-partner and partner-to-IKZF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPM grouped by IKZF2-low versus IKZF2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (IKZF2→partner) and Y-score (partner→IKZF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CENPM →	+0.651	+3.217	<.001	<.001	3	3
SKCM	UBE2S →	+0.639	+3.195	<.001	<.001	3	3
UCEC	KIF20A →	+0.527	+2.906	.005	.001	3	3
UCEC	FAM98C →	+0.317	+2.279	.002	<.001	3	3
SKCM	COQ3 →	+0.509	+2.714	<.001	<.001	3	3
UCEC	PKN3 →	+0.705	+2.180	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,095 associations by consensus.

CENPM by IKZF2 expression — SKCM

Explore this box plot interactively →