IKZF2

Across TCGA pan-cancer cohorts, IKZF2 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of IKZF2’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where IKZF2 RNA is repressed in tumor relative to normal tissue. In most cancer types IKZF2 is over-expressed in tumor, although a few such as HNSC and KICH show the opposite, repressed pattern.

HNSC, LUAD, and KICH are the cancer types where IKZF2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in IKZF2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	−1.549	<.001	12	view →
LUAD	Female	All	+0.711	<.001	8	view →
KICH	Male	All	−0.999	<.001	7	view →
BLCA	All	IV	+1.899	.016	6	view →
THCA	All	All	+0.492	.002	5	view →
BRCA	All	II,III,IV	+0.483	<.001	4	view →
COAD	Female	All	−0.452	<.001	4	view →
CHOL	All	All	+0.755	.008	2	view →
LUSC	All	All	+0.278	.037	1	view →
KIRC	Male	All	+0.261	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

IKZF2–HNSC

Open the HNSC breakdown →